(annually)

This seminar focuses on major issues in research protocol development, including methodologic issues regarding different research designs, development of research questions, and plans for analysis. Each student will present his or her research protocol for open discussion during one of the seminar sessions.

This seminar focuses on techniques for critical appraisal of the medical literature. Each student will be responsible for at least one critical appraisal session covering different epidemiologic topics (including the evaluation of diagnostic tests, clinical course and prognosis of disease, disease etiology or causation, therapy, quality of clinical care, economic evaluation, and meta-analysis). Each week, a student will critically appraise a journal article and lead the discussion concerning that article.

Recent advances have made it feasible to incorporate data on potential genetic risk factors into traditional epidemiologic studies. Hence, there is an increasing need for epidemiologists to understand the genetic basis of disease, read, and interpret genetic studies, and incorporate the collection and analysis of genetic information into studies of disease etiology. The objectives of this course are to provide epidemiologists with an understanding of: 1) basic genetics, 2) the tools used by geneticists and genetic epidemiologists, and 3) the integration of genetic data into traditional epidemiologic study designs. After completing this course, students will be able to read and interpret genetic epidemiologic studies. In addition, they will be able to design epidemiologic studies that incorporate genetic data collection and analysis.

An introduction to the principles of and methods for longitudinal and clustered data analysis with special emphasis on clinical, epidemiologic, and public health applications. Designed for advanced MS and PhD-level students in epidemiology and related fields. Marginal and conditional methods for continuous and binary outcomes. Mixed effects and hierarchical models. Simulations for power calculations. Software will include Stata and R. Prerequisite: Completion of EPID 5260 and 5270 or equivalent preparation in biostatistics, including generalized linear models. Completion of semester curse in principles of epidemiology or equivalent. Good working knowledge of Stata and SAS and familiarity with principles of first-year calculus and matrix algebra. Permission of course director.

This course will provide in-depth treatment of several topics in categorical data analysis. After a brief review of methods for contingency tables, we will introduce the idea of generalized linear models, and focus on two special cases – multiple logistic regression and log-linear models. Each topic will be presented in detail by stating the model and covering parameter estimation and interpretation, inference, model building, regression diagnostics, and assessment of model fit. Finally, we will cover extensions to both models, including models for multinomial data, analysis of matched-pair data, and random effects models. Topics will be illustrated in class with examples, and we will discuss the use of Stata to conduct the analyses.

This course is designed to introduce students to advanced epidemiologic methods through a series of readings and discussions. The course aims to deepen the students’ understanding of important concepts and controversies in contemporary epidemiology and to enhance their ability to think critically about empirical epidemiologic research. The course is intended for students who are already familiar with the fundamentals of epidemiology and biostatistics, and who wish to gain an understanding of the complex issues underlying epidemiologic study design and interpretation. Each week, one student will be responsible for leading a portion of the discussion of the assigned readings, in conjunction with a faculty member. Topics include: causal inference; study designs; use of large databases for research; predicting outcomes; and complex sampling methods.

This is an advanced course that addresses epidemiologic research issues as they apply to important clinical topics in cardiovascular and pulmonary medicine. Lectures and workshops are designed to acquaint students with the classic literature in the fields of cardiovascular and pulmonary epidemiology, to use a body of literature to demonstrate the strengths and weaknesses of epidemiologic research designs as they have been applied to cardiovascular and pulmonary medicine, to expose students to the range of topics studied, to teach advanced epidemiologic principles using a problem-based approach, and to stimulate students to develop independent research questions.

Research in cancer etiology, prevention, treatment, and control includes a wide range of subject matter science, from the initial molecular changes that precede the development of cancer to issues of primary care guidelines for cancer survivors. The course reviews the possible study designs applied to cancer etiology, prevention, treatment, and control. These include randomized controlled trials and multiple types of observational studies (cohort, case-control, cross-sectional). Other topics will include causal inference, bias, and effect modification.