CCEB Seminar- James Flory, MD, MSCE

"Metformin Pharmacoepidemiology: Some Interesting Facts About Prescribing Patterns and Some Attempts at Causal Inference" James H. Flory, MD, MSCE Assistant Professor in the Department of Health Policy and Research at Weill Cornell Medical College, and an Assistant Attending on the Endocrinology Service at Memorial Sloan Kettering Cancer Center I am an endocrinology fellow and board certified internist. My time and expertise are divided between patient care and academic research.  Clinically, my focus is in type 2 diabetes, with secondary interests in type 1 diabetes, bone health, and thyroid disease. I have particularly extensive experience managing these conditions in oncology patients. As a researcher, I am a specialist in using observational data (rather than clinical trial data) to study the safety and comparative effectiveness of medical treatments. I collaborate on projects in this area with investigators at Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center, the Perelman School of Medicine at the University of Pennsylvania, and the Food and Drug Administration. Some specific areas that I study are the safety and tolerability of metformin (the most widely used diabetes medication) and the optimal choice of second line drugs for diabetes after metformin. Methodologically my particular interests include the analysis of 'messy' longitudinal biomarker data using mixed linear models, missing data issues, instrumental variables, and simulation of clinical trials using observational results.